Natural Products in Drug discovery: Current Trends
Keywords:
Natural products, Drug discovery, Medicinal chemistry, Drug designs, Automation, Artificial intelligence (AI), developmentAbstract
Medical chemicals have been found in nature for thousands of years, and a staggering number of modern medicines have been shown to have natural roots. For many years, people have employed plants as herbal remedies to cure a variety of illnesses, and the numerous natural compounds they produce have served as inspiration for the creation of new medications. This demand will be met in large part by natural goods via the ongoing investigation of the world's biodiversity, much of which is yet unknown. In this article review the various literature’s study on “natural products in drug discovery”. In conclusion, natural products have been a fundamental component of drug discovery for an extended period, providing useful lead compounds for the development of new therapeutics. Advances in technology have enhanced the selection, identification, and optimization of plant-derived phytochemicals, improving their efficacy and safety. Despite challenges in natural product development, innovative strategies continue to drive drug discovery, addressing both communicable and non-communicable diseases. Plant-based biologics have been further emphasised as a potential vaccine development strategy during the COVID-19 pandemic. In areas such as "immunosuppression, anti-infectives, and metabolic disorders", natural products continue to be a critical source of innovative treatments, as a result of the renewed interest in them as a result of the constraints of alternative drug discovery methodologies.
References
[1] G. Atanasov, S. B. Zotchev, V. M. Dirsch, and C. T. Supuran, "Natural products in drug discovery: advances and opportunities," Nat. Rev. Drug Discov., vol. 20, no. 3, pp. 200-216, 2021,https://doi.org/10.1038/s41573-020-00114-z
[2] S. P. Singh, S. K. Shukla, and R. Yadav, "Artificial intelligence and Machine learning- based approaches for Neurodegenerative Diseases Diagnosis," pp. 31-37, 2023.
[3] J. B. Calixto, "The role of natural products in modern drug discovery.," An. Acad. Bras. Cienc., vol. 91, pp. 1-7, 2019,https://doi.org/10.1590/0001-3765201920190105
[4] J. Ribeiro-Filho, Y. C. F. Teles, J. O. Igoli, and R. Capasso, "Editorial: New trends in natural product research for inflammatory and infectious diseases," Front. Pharmacol., vol. 13, no. August, pp. 1-4, 2022,https://doi.org/10.3389/fphar.2022.975079
[5] M. Lahlou, "The Success of Natural Products in Drug Discovery," Pharmacol. & Pharm., vol. 04, no. 03, pp. 17-31, 2013,https://doi.org/10.4236/pp.2013.43A003
[6] S. Sahu, J. Boaddh, and V. S. Pawar, "Machine Learning in Diabetes Diagnosis : A Comprehensive Review," pp. 80-85, 2024,https://doi.org/10.69968/ijisem.2024v3i480-85
[7] D. Wright, "Unlocking the potential of natural products in drug discovery," Microb. Biotechnol., vol. 12, no. 1, pp. 55-57, 2019,https://doi.org/10.1111/1751-7915.13351
[8] Najmi, S. A. Javed, M. Al Bratty, and H. A. Alhazmi, "Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents," Molecules, vol. 27, no. 2, 2022,https://doi.org/10.3390/molecules27020349
[9] N. Chaachouay and L. Zidane, "Plant-Derived Natural Products: A Source for Drug Discovery and Development," Drugs Drug Candidates, vol. 3, no. 1, pp. 184-207, 2024,https://doi.org/10.3390/ddc3010011
[10] N. E. Thomford et al., "Natural products for drug discovery in the 21st century: Innovations for novel drug discovery," Int. J. Mol. Sci., vol. 19, no. 6, 2018,https://doi.org/10.3390/ijms19061578
[11] T. Zeng, J. Li, and R. Wu, "Natural Product Databases for Drug Discovery: Features and Applications," Pharm. Sci. Adv., vol. 2, no. August, p. 100050, 2024,https://doi.org/10.1016/j.pscia.2024.100050
[12] Jalil, J. M. Rollinger, A. G. Atanasov, R. K. Singla, A. D. Kinghorn, and M. Heinrich, "Core publications in drug discovery and natural product research," no. November, pp. 1-12, 2024,https://doi.org/10.3389/fntpr.2024.1493720
[13] R. Shrivastava, G. Modi, P. S. Satpathy, S. Bandyopadhyay, Y. Kumar, and I. Yadav, "Natural Products Revolutionizing and Innovative Drug Discovery and Development Strategies: Healthcare Challenges and Future Perspectives," J. Appl. Bioanal., no. July, 2024,https://doi.org/10.53555/jab.v10i1.76
[14] G. Conrado, R. da Rosa, R. D. Reis, and L. R. Pessa, "Building Natural Product-Based Libraries for Drug Discovery: Challenges and Opportunities from a Brazilian Pharmaceutical Industry Perspective," Rev. Bras. Farmacogn., vol. 34, no. 4, pp. 706-721, 2024,https://doi.org/10.1007/s43450-024-00540-9
[15] J. Newman and G. M. Cragg, "Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019," J. Nat. Prod., vol. 83, no. 3, pp. 770-803, 2020,https://doi.org/10.1021/acs.jnatprod.9b01285
[16] R. Sj and N. P. Shetty, "Advances in designing Next-generation drugs from Natural products," pp. 1-21, 2024.https://doi.org/10.22541/au.170665860.06156857/v1
[17] J. Newman, "Natural products and drug discovery," Natl. Sci. Rev., vol. 9, no. 11, 2022,https://doi.org/10.1093/nsr/nwac206
[18] N. Nasim, I. S. Sandeep, and S. Mohanty, "Plant-derived natural products for drug discovery: current approaches and prospects," Nucl., vol. 65, no. 3, pp. 399-411, 2022,https://doi.org/10.1007/s13237-022-00405-3
[19] Chopra and A. K. Dhingra, "Natural products: A lead for drug discovery and development," Phyther. Res., vol. 35, no. 9, pp. 4660-4702, 2021,https://doi.org/10.1002/ptr.7099
[20] P. S. Tresina, M. S. Selvam, A. Rajesh, A. Doss, and V. R. Mohan, "Natural Products in Drug Discovery: Approaches and Development," J. Pharm. Res. Int., vol. 33, pp. 93-110, 2021,https://doi.org/10.9734/jpri/2021/v33i35A31879
