Advances in Drug Design: Techniques and Strategies
Keywords:
Drug design, Computer-Aided Drug Design (CADD) techniques, Structure-Based Drug Design, Ligand Based Drug Design, Artificial intelligence (AI), drug discoveryAbstract
Drug design is an ancient and intricate pharmaceutical discipline. Since Emil Fisher proposed at the end of the 19th century that the interaction between a medication and its receptor is similar to that between a key and a lock, many advancements have been achieved in the area of drug design. Drug design has steadily evolved into a logical, well-structured discipline with a strong theoretical foundation and real-world applications. Examine the many studies conducted by researchers on drug creation approaches and tactics in this page. According to the review, a number of methods, including metabolomics, genomics, and proteomics, complement other approaches well. Additionally, the most recent drug design techniques can be used to find drug molecules with higher target specificity, accuracy, and safety at a lower cost and in a shorter amount of time. Furthermore, recent drug development efforts across a variety of disorders heavily rely on "Computer-Aided Drug Design (CADD)" methodologies. Computer approaches have significantly accelerated the development and optimisation of potential therapeutic medications.
References
[1] M. Shah, M. Patel, M. Shah, M. Patel, and M. Prajapati, "Computational transformation in drug discovery: A comprehensive study on molecular docking and quantitative structure activity relationship (QSAR)," Intell. Pharm., vol. 2, no. 5, pp. 589-595, 2024,https://doi.org/10.1016/j.ipha.2024.03.001
[2] I. Azad, T. Khan, N. Ahmad, A. R. Khan, and Y. Akhter, "Updates on drug designing approach through computational strategies: A review," Futur. Sci. OA, vol. 9, no. 5, 2023,https://doi.org/10.2144/fsoa-2022-0085
[3] W. Yang, Y. Wang, D. Han, W. Tang, and L. Sun, "Recent advances in application of computer-aided drug design in anti-COVID-19 Virials Drug Discovery," Biomed. Pharmacother., vol. 173, p. 116423, 2024,https://doi.org/10.1016/j.biopha.2024.116423
[4] S. Jaiswal, "The Impact of Artificial Intelligence on Organizational Development: A Case Study of Medanta," Int. J. Innov. Sci. Eng. Manag., vol. 528, pp. 793-807, 2024,https://doi.org/10.1007/978-3-031-56586-1_58
[5] I. Doytchinova, "Drug Design-Past, Present, Future," 2022.https://doi.org/10.3390/molecules27051496
[6] A. Premalatha, M. Atul Bora, D. Bhoomandla, and A. Kumari Nakkella, "Recent Advances in Drug Discovery: Innovative Approaches and Targeted Therapeutics," Chem. Bull, vol. 2023, no. September, p. 2068, 2023.
[7] N. Singh, P. Vayer, S. Tanwar, J.-L. Poyet, K. Tsaioun, and B. O. Villoutreix, "Drug discovery and development: introduction to the general public and patient groups," Front. Drug Discov., vol. 3, no. May, pp. 1-11, 2023,https://doi.org/10.3389/fddsv.2023.1201419
[8] Shamima Shultana, Kazi M Maraz, Arwah Ahmed, Tanzila Sultana, and Ruhul A Khan, "Drug design, discovery and development and their safety or efficacy on human body," GSC Biol. Pharm. Sci., vol. 17, no. 2, pp. 113-122, 2021,https://doi.org/10.30574/gscbps.2021.17.2.0330
[9] Dheeraj Bisht, Rajeshwar Kamal Kant Arya, Govind Raj Pal, and Ravindra Pratap Singh, "A Review on Recent Rational Approaches to Drug Design, Development and Its Discovery," Int. J. Life Sci. Pharma Res., vol. 10, no. 4, pp. 96-108, 2020,https://doi.org/10.22376/ijpbs/lpr.2020.10.4.P96-108
[10] G. M. Nitulescu, "Techniques and Strategies in Drug Design and Discovery," Int. J. Mol. Sci., vol. 25, no. 3, pp. 24-26, 2024,https://doi.org/10.3390/ijms25031364
[11] M. S. Alshehri, "GREEN CHEMISTRY STRATEGIES IN DRUG DISCOVERY AND DEVELOPMENT," vol. 30, no. 18, pp. 242-249, 2023, doi: 10.53555/jptcp.v30i18.3065.
[12] K. Wu, E. Karapetyan, J. Schloss, J. Vadgama, and Y. Wu, "Advancements in small molecule drug design: A structural perspective," Drug Discov. Today, vol. 28, no. 10, pp. 1-27, 2023,https://doi.org/10.1016/j.drudis.2023.103730
[13] P. Dixit and P. B. Singh, "The Impact of Artificial Intelligence on Various Sectors: Benefits, Challenges, and Future Prospects," Interantional J. Sci. Res. Eng. Manag., vol. 08, no. 04, pp. 1-5, 2024,https://doi.org/10.55041/IJSREM30655
[14] G. Biala et al., "Research in the Field of Drug Design and Development," Pharmaceuticals, vol. 16, no. 9, 2023,https://doi.org/10.3390/ph16091283
[15] G. K. Kiriiri, P. M. Njogu, and A. N. Mwangi, "Exploring different approaches to improve the success of drug discovery and development projects: a review," Futur. J. Pharm. Sci., vol. 6, no. 1, 2020,https://doi.org/10.1186/s43094-020-00047-9
[16] S. K. Niazi and Z. Mariam, "Computer-Aided Drug Design and Drug Discovery: A Prospective Analysis," Pharmaceuticals, vol. 17, no. 1, pp. 1-22, 2024,https://doi.org/10.3390/ph17010022
[17] R. B. O. Ouma, S. M. Ngari, and J. K. Kibet, A review of the current trends in computational approaches in drug design and metabolism. BioMed Central, 2024.https://doi.org/10.1186/s12982-024-00229-3
[18] P. K. Gupta, Y. Pal, P. Kumar, S. Gupta, S. D. Singh, and S. B. Tiwari, "A Critical Review on Computational Techniques through in silico Assisted Drug Design," vol. 14, no. 4, pp. 1035-1041, 2024,https://doi.org/10.5530/ijpi.14.4.113
[19] U. Naithani and V. Guleria, "Integrative computational approaches for discovery and evaluation of lead compound for drug design," Front. Drug Discov., vol. 4, no. April, pp. 1-11, 2024,https://doi.org/10.3389/fddsv.2024.1362456
[20] K. Elizabeth and E. Amalia, "Approaches for Drug Design and Discovery," Indones. J. Pharm., vol. 4, no. 2, pp. 242-254, 2022.
